XPO1 编码一种介导蛋白质和RNA核输出的蛋白。XPO1识别含有核输出信号（NES）的蛋白质，并引起其从细胞核向细胞质的外排。据报道，XPO1通过与NDM3结合输出60S核糖体亚基，参与核糖体的生物合成。在癌症的背景下，XPO1具有致癌特性，这主要归因于XPO1输出的蛋白包括重要的肿瘤抑制因子（例如APC，TP53，SMARCB1等）。XPO1在细胞核中的高表达在多种肿瘤中具有不同的预后，并且XPO1突变已经在一些慢性淋巴白血病（CLL）和弥漫性大B细胞淋巴瘤（DLBCL）有过报道。XPO1易位在T-ALL中已有报道。

The XPO1 (Exportin 1) encodes a protein that mediates nuclear export of proteins and RNA. XPO1 recognizes proteins containing a nuclear export signal (NES) and leads to their export from the nucleus to the cytoplasm. XPO1 has been reported to be involved in ribosome biogenesis by exporting the 60S ribosome subunit through binding to NMD3. In the context of cancer, XPO1 has oncogenic properties. This has been mostly attributed to the fact that proteins exported by XPO1 include important tumor suppressors (eg. APC, TP53, SMARCB1 etc.). High nuclear XPO1 expression is associated with adverse prognosis in various tumor entities and XPO1 mutations have been reported in some cases of chronic lymphatic leukemia (CLL) as well as diffuse large B-cell lymphoma (DLBCL). XPO1 translocations have been reported in T-ALL. Small molecule inhibitors of nuclear export (SINEs) have been developed and tested in preclinical studies in various tumor types and show promising therapeutic efficacy.

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