SS18
小结
SS18编码蛋白是NBAF染色质重塑复合物亚基，其相关信号途径包括癌症中的转录错误调节和染色质调节/乙酰化。有研究显示，SS18与RBM14协同作用作为转录共激活因子，同种型1和同种型2在核受体共激活中起作用。SS18的一个重要的旁系同源物是SS18L1。与SS18相关的疾病包括肉瘤。
SS18 is a member of the human SWI/SNF chromatin remodeling complex. Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.