SRC
小结
SRC是致癌基因，编码蛋白（c-SRC）是一种非受体酪氨酸蛋白激酶，其参与细胞周期调控、胞质分裂、细胞存活/增殖和迁移/运动。c-SRC与另外的九个非受体酪氨酸激酶密切相关，它们与c-SRC同源（SRC家族激酶（SFK）），发挥相似的功能，与人类癌症有关。c-SRC与多种人类恶性肿瘤密切相关，常见的相关癌症包括结直肠癌和乳腺癌等。
SRC encodes the c-SRC proto-oncogene, a non-receptor tyrosine protein kinase implicated in cell cycle control, cytokinesis, cell survival/ proliferation and migration/motility. Furthermore, c-SRC has been strongly correlated with a variety of human malignancies including colorectal and breast cancer among others. The c-SRC protein consists of a N-terminal myristolation sequence, important for membrane localization and subsequent functionality, followed by an unique SH4 domain, a SH3 domain, a SH2 domain, a linker to the protein-tyrosine kinase domain and a C-terminal regulatory domain. c-SRC is closely related to nine additional non-receptor tyrosine kinases that share homology with c-SRC, the SRC Family Kinases (SFK), which exert similar functions and are also implicated in human cancers.