SOCS1编码蛋白是一种细胞因子信号转导的蛋白抑制剂，其基因表达是由细胞因子刺激诱导，并在细胞因子信号的负反馈抑制中起作用。SOCS1与受体和非受体激酶上的磷酸酪氨酸相结合，以介导细胞因子信号传导的抑制。SOCS1调节细胞因子信号对于有效的免疫调节和淋巴细胞发育是重要的。在霍奇金淋巴瘤和原发性纵隔淋巴瘤中发现SOCS1的体细胞功能性缺失突变。SOCS1突变表现为截短突变，并导致激活的JAK-STAT激酶信号转导，提示SOCS1作为肿瘤抑制因子发挥作用。SOCS1转录的沉默也已在髓系疾病、白血病、卵巢癌和乳腺癌中得到证实。

SOCS1 is a protein suppressor of cytokine signaling whose gene expression is induced by cytokine stimulation and which functions in negative feedback inhibition of cytokine signaling. SOCS1 binds the phosphotyrosines on receptor and non-receptor kinases to mediate inhibition of cytokine signaling. In addition, SOCS1 can target proteins for degradation via the SOCS box domain. Regulation of cytokine signaling by SOCS1 is important for effective immune regulation and lymphocyte development. Somatic loss-of-function SOCS1 mutations have been found in Hodgkin’s lymphoma and primary mediastinal lymphomas. SOCS1 mutations present as truncating mutations and lead to activated JAK-STAT kinase signaling, suggesting that SOCS1 functions as a tumor suppressor. Silencing of SOCS1 transcription has also been identified in myeloid diseases, leukemias, ovarian cancer and breast cancer.

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