SDHC是抑癌基因，编码蛋白是琥珀酸脱氢酶C（SDHC）是琥珀酸脱氢酶（SDH）复合物的四种组分之一，并且是线粒体电子传递链中的关键酶。SDHA和SDHB形成SDH复合物的催化结构域，SDHC和SDHD将复合物锚定到线粒体内膜，SDHC和其他SDH复合家族成员起肿瘤抑制作用，这些基因的功能丧失突变已证明可稳定缺氧诱导因子（HIF），从而导致促进肿瘤发生的低氧状态。SDH基因突变与嗜铬细胞瘤、副神经节瘤、胃肠道间质瘤（GIST）、肾细胞癌和垂体腺瘤的发生有关。SDH基因的胚系功能缺失性突变（包括SDHB），可导致遗传性副神经节瘤和嗜铬细胞瘤。

SDHC (Succinate dehydrogenase C) is one of the four components of the succinate dehydrogenase (SDH) complex and is a critical enzyme in the mitochondrial electron transport chain. While SDHA and SDHB form the catalytic domain of the SDH complex, SDHC and SDHD anchor the complex to the inner mitochondrial membrane. SDHC and other SDH complex family members function as tumor suppressors; loss of function mutations in these genes have been shown to stabilize hypoxia-inducible factors (HIF), thus leading to a hypoxic state that promotes tumorigenesis. SDH mutations have been involved in the pathogenesis of pheochromocytomas, paragangliomas, gastrointestinal stromal tumors (GISTs), renal-cell carcinomas and pituitary adenomas. Mutations in components of the SDH complex lead to accumulation of succinate, which can competitively inhibit the action of alpha-ketoglutarate-dependent histone- and DNA-demethylases in a variety of cancers and lead to a hypermethylator phenotype. Germline loss of function mutations in the SDH genes can cause hereditary paraganglioma and pheochromocytoma.

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