ROS1
小结
ROS1是致癌基因，编码蛋白是具有细胞内酪氨酸激酶活性的跨膜蛋白。ROS1是酪氨酸激酶胰岛素受体基因的七个亚家族的一名成员。该蛋白质在人体中的正常生理作用和配体目前未知。激酶结构域保留的ROS1重排涉及一系列人类上皮癌，包括胆管癌，卵巢癌，胃癌，血管肉瘤和最常见的非小细胞肺癌。ROS1重排导致失调的激酶活性的机制尚不清楚，因为其配体目前未知。
The ROS1 gene encodes a transmembrane protein with intracellular tyrosine kinase activity. ROS1 is a member of the sevenless subfamily of tyrosine kinase insulin receptor genes. The normal physiological role and ligand of this protein in humans is currently unknown. ROS1 rearrangements where the kinase domain is retained are implicated in a range of human epithelial cancers including cholangiocarcinoma, ovarian carcinoma, gastric carcinoma, angiosarcoma and most commonly non-small cell lung cancer. Although ROS1 rearrangements were first discovered in a human glioblastoma cell line, there is a paucity of ROS1 rearrangements in human gliomas. The mechanism by which ROS1 rearrangements leads to dysregulated kinase activity is not clear, as its ligand has not yet been deciphered; however, it is hypothesized to occur through constitutive kinase activation.