RAD54L编码蛋白是SNF2-解旋酶家族的成员，其作为染色质重塑蛋白起作用，参与DNA双链断裂修复。RAD54L与中心同源修复蛋白RAD51结合，并在DNA中形成拓扑变化，导致DNA配对和重组。还有证据表明RAD54L可以在重组开始后将RAD51与双链DNA解离。在人类癌症中，RAD54L的体细胞改变发生频率很低。目前发现， RAD54L的突变存在于非霍奇金淋巴瘤和慢性淋巴细胞白血病以及乳腺癌，结肠癌等癌症中。

RAD54L is a member of the SNF2-family of helicases that functions as a chromatin remodeling protein for the repair of double-stranded breaks during homologous recombination and repair. RAD54L binds to RAD51, the central homologous repair protein, and facilities a topological change in the DNA leading to DNA pairing and recombination. The RAD54L-RAD51 interaction results in supercoiling ahead of replication factor complex movement and the stabilization of the D loops durin. There is additional evidence that RAD54L can disassociate RAD51 from duplex DNA after recombination has been initiated. Mutations in RAD54L have been identified in breast cancers, colon cancers, and lymphomas, however, somatic alterations of RAD54L in human cancers are infrequent.

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