PRKCI
小结
PRKCI是致癌基因，编码蛋白是蛋白激酶C iota，是一种非典型的丝氨酸/苏氨酸激酶，参与多种细胞过程。PRKCI保护BCR-ABL白血病细胞免于凋亡。它还通过NF-KB通路的激活增强细胞增殖和存活。PRKCI促进体内的集落形成和肿瘤生长，在肺癌中与SOX2协同激活Hedgehog信号通路。PRKCI对胶质瘤中的BAD进行磷酸化，而使它们逃脱凋亡。PRKCI经常在几种癌症中通过扩增的方式发生变异，包括肺癌、卵巢癌、食管癌和头颈部癌。
The PRKCI gene encodes the protein kinase C iota, an atypical serine/threonine kinase involved in multiple cellular processes. PRKCI protects BCR-ABL leukemia cells from undergoing apoptosis. It also enhances cell proliferation and survival via NF-KB pathway activation. PRKCI promotes colony formation and tumor growth in vivo and cooperates with SOX2 to activate the Hedgehog signaling pathway in lung cancers. PRKCI phosphorylates BAD in glioma cells, thus allowing them to evade apoptosis. PRKCI is frequently altered by amplification in several cancers, including lung, ovarian, esophageal and head and neck carcinomas.