PRDM1是抑癌基因，编码蛋白是PR结构域锌指1（PRDM1），也称为BLIMP-1和PRDI-BF1，其是一种含五个锌指结构的DNA结合蛋白。PRDM1参与细胞对病毒感染和B细胞分化的反应。PRDM1最初被描述为干扰素β的转录阻遏物，并作为B细胞分化的重要成分。PRDM1已被证明通过与Groucho家族的转录共阻遏物以及组蛋白修饰因子相互作用来发挥作用。实验结果表明PRDM1是生殖细胞谱系、T细胞分化、体内平衡和心脏功能建立的重要因素。位于PRDM1和ATG5基因间的两个单核苷酸多态性（SNPs），与放疗诱导的儿童霍奇金淋巴瘤放疗后第二次恶性肿瘤风险增加有关。

PRDM1, also known as BLIMP-1 and PRDI-BF1, encodes PR domain zinc finger 1 (PRDM1), a DNA-binding protein with five zinc fingers. PRDM1 was initially described as a transcriptional repressor of interferon ß, and as an essential component of B cell differentiation, wherein it represses MYC. It has been shown to function by interaction with the Groucho family of transcriptional co-repressors as well histone-modifying factors. More recent results from animal studies indicate PRDM1 as an important factor in establishment in the germ cell lineage, T cell differentiation and homeostasis and heart function. Two single-nucleotide polymorphisms (SNPs) located intergenic to PRDM1 and ATG5 have been associated with increased risk for radiation therapy–induced second malignant neoplasms after radiotherapy for pediatric Hodgkin's lymphoma.

GeneCards OncoKB My Cancer Genome