PPP2R1A编码蛋白是蛋白磷酸酶2A（PP2A），是一种参与细胞生长和分裂的丝氨酸/苏氨酸磷酸酶。PP2A长期以来被认为是一种重要的抑癌因子，尽管最近的证据表明在某些背景条件下它可能作为癌基因发挥作用。研究发现PPP2R1A突变与人类癌症的全基因组倍增呈正相关。PPP2R1A突变已确定在子宫（子宫内膜）癌，子宫（浆液性）癌，卵巢低级别浆液性，低级别子宫内膜样，透明细胞和粘液癌中检测到。

The PPP2R1A gene encodes protein phosphatase 2A (PP2A) a serine/threonine phosphatase involved in cell growth and division. PP2A activity has long been considered an important tumor suppressor, although recent evidence suggests that it may function as an oncogene in some context. The PPP2R1A gene encodes the 'scaffolding' subunit of the PP2A trimeric holoenzyme, so named because it bridges PP2A's catalytic subunit to a myriad of targeting subunits. Targeting subunits confer specificity for substrate selection and enzyme localization in the cell. PPP2R1A mutations have recently been found to positively correlate with whole-genome doublings in human cancers. These mutations have been identified in uterine (endometrial) carcinomas, uterine (serous) carcinomas, ovarian low-grade serous, low-grade endometrioid, clear cell, and mucinous carcinomas. The functional impact of these mutations during tumorigenesis is limited, however, the available studies describing these mutations indicate that normal function of PPP2R1A is tumor suppressive.

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