PIK3R2编码蛋白是PI3K的调节亚基，又称p55-β，其功能是通过直接相互作用来调节活化受体酪氨酸激酶（RTKs）。因此，其在调节细胞内的各种下游活动，如生长、增殖和运动是重要的。在RTK活化后，PIK3R2有助于募集PI3K酶复合物到细胞膜，并允许PI3K催化亚基产生磷脂酰肌醇-3，4-，5-三磷酸（PIP3），PIP3激活下游信号通路如AKT-mTOR。PIK3R2突变常见于野生型PTEN的子宫内膜癌，但在多种癌症中发生突变的频率较低。

PIK3R2 encodes a regulatory subunit of PI3-kinase, a component of the pro-oncogenic PI3-kinase/AKT/mTOR signaling pathway. PIK3R2 is mutated at low frequencies in a diverse range of cancer. PIK3R2, also known as p55-β, is a regulatory subunit of PI3K and functions to regulate activated receptor tyrosine kinases (RTKs) via direct interaction. It is thus important in regulating various downstream activities in the cell, such as growth, proliferation and motility. Upon RTK activation, PIK3R2 helps recruit the PI3K enzymatic complex to the cell membrane and allows the PI3K catalytic subunit to generate phosphatidylinositol-3, 4, 5-trisphosphate (PIP3), which is important in activating downstream signaling pathways such as AKT-mTOR. PIK3R2 mutations are often found in endometrial cancers with wildtype PTEN, and allow for increased PI3K and downstream AKT signaling.

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