PIK3CG编码蛋白（磷脂酰肌醇-4，5-双磷酸酯酶3-激酶催化亚基γ）也称为P110γ，是PI3激酶的I类催化亚基，并作为一种磷脂酰肌醇磷酸化的脂质和蛋白激酶。PIK3CG参与细胞外信号转导，并将细胞表面受体连接到细胞内信号转导网络，如PI3激酶/Akt通路。一旦激活，Akt-mTOR下游信号促进细胞存活、增殖、生长和运动。PIK3CG主要在白细胞中表达，并通过与RAS和G蛋白偶联受体（GPCRs）的直接相互作用在免疫细胞反应和炎性刺激中起重要作用。PIK3CG的失活突变存在于子宫癌，子宫内膜癌，皮肤癌和肺癌中，另外，PIK3CG缺失在髓系恶性肿瘤中也常被发现。

PIK3CG encodes a kinase involved in modulation of the extracellular signal. Inactivating mutations of PIK3CG are found in uterine, endometrial, skin and lung cancers, among others. PIK3CG (phosphatidelinositol-4, 5-bisphophsphate3-kinase catalytic subunit gamma), also known as p110-gamma, is a class I catalytic subunit of PI3-kinase and acts as a lipid and protein kinase that phosphorylates phosphoinositides. PIK3CG is involved in extracellular signaling and linking cell-surface receptors to intracellular signaling networks, such as the PI3-kinase/AKT pathway. Once activated, AKT-mTOR downstream signaling promotes cell survival, proliferation, growth and motility. PIK3CG is primarily expressed in white blood cells, and through its direct interactions with RAS and G-protein coupled receptors (GPCRs) is important in immune cell responses and inflammatory stimuli. While deletions of PIK3CG are often found in myeloid malignancies in conjunction with broad 7q22 deletion, PIK3CG is not likely a tumor suppressor in these settings.

GeneCards OncoKB My Cancer Genome