PIK3C2G编码蛋白使PI3-激酶的II类催化亚基，PIK3C2G充当脂质激酶，产生磷脂酰肌醇-3,4-二磷酸，作为参与细胞周期，运动，分化和转化的关键信号通路的第二信使。PIK3C2G是参与细胞增殖，致癌转化和蛋白质运输信号传导途径的激酶。在黑素瘤，肺癌，胃肠癌中发现PIK3C2G的失活突变，并在许多癌症中发生突变。

PIK3C2G encodes a kinase involved in cell proliferation, oncogenic transformation and protein trafficking signaling pathways. Inactivating mutations of PIK3C2G are found in melanomas and lung and gastrointestinal cancers.PIK3C2G is a class II catalytic subunit of PI3-Kinase. PIK3C2G acts as a lipid kinase to create phosphatidylinositol-3, 4-bisphosphate (PtdIns(3, 4)P2), which acts as a secondary messenger in key signaling pathways involved in cell cycle, motility, differentiation and transformation. Class II PI3Ks are the least studied, however, they are defined by the presence of a carboxyl-terminal calcium-dependent phospholipid-binding

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