PDCD1LG2编码蛋白（程序性细胞死亡1配体2）PD-L2蛋白。PD-L2与PD-L1高度相似，是一种由肿瘤细胞和抗原呈递细胞（APC）过表达导致T细胞受体 （TCR）信号传导和随后的肿瘤免疫逃避的负调节的蛋白质。PD-L2对PD-1的结合亲和力高于PD-L1。PD-L2也在活化的T辅助细胞2型（Th2）中表达，抑制其功能并调节IFN-γ的产生。PDCD1LG2过表达或扩增在肾、宫颈和乳腺癌等癌症中已有报道，在某些情况下预测预后不良。PDCD1LG2是癌症免疫治疗的一个预测靶点。

PDCD1LG2, a ligand of T-cell receptors involved in immune suppression, is overexpressed in various cancer types.The PDCD1LG2 gene encodes the "programmed cell death 1 ligand 2" (PD-L2) protein. PD-L2 is highly similar to PD-L1, a protein whose overexpression by tumor cells and antigen presenting cells (APC) leads to negative regulation of T-cell receptor (TCR) signaling and subsequent tumor immune evasion. PD-L2 binding affinity for PD-1 is higher than PD-L1, although the biological consequences of this are unknown. PD-L2 is also expressed in activated T-helper cells type 2 (Th2), inhibiting its function and regulating IFN-γ production. Impaired tumor growth has been observed in several in vitro and in vivo cancer models upon dual PD-L1/PD-L2 inhibition, but the specific additive role for the latter remains elusive. PDCD1LG2 overexpression or amplification has been reported in renal, cervical and breast cancers, among others, and in some cases predicts poor prognosis. PDCD1LG2 is a putative target for cancer immunotherapy.

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