PARK2
小结
PARK2是抑癌基因，编码蛋白是parkin蛋白，其是E3-泛素连接酶复合物的组分，用于标记细胞蛋白质以降解。 PARK2蛋白通过与泛素蛋白缀合酶（包括UBCH7和UBCH7）相互作用而发挥功能。PARK2通过调节蛋白质稳定性，在几个有助于肿瘤发生的分子过程中起作用，包括但不限于细胞周期进展，线粒体稳态和细胞凋亡。PARK2的胚系突变与家族性肺癌有关；PARK2在各种癌症类型中失活，其功能障碍与遗传性帕金森病有关。
PARK2 encodes a tumor suppressor invovled in tagging cellular proteins for degradation. PARK2 is inactivated in various cancer types, and its dysfunction is associated with hereditary Parkinson's disease. PARK2 encodes the parkin protein, which is a component of an E3-ubiquitin ligase complex that serves to mark proteins for proteasomal degradation. The PARK2 protein functions through physical interaction with ubiquitin-conjugating enzymes, including UBCH7 and UBCH7. Through regulation of protein stability, PARK2 plays a role in several molecular processes which contribute to oncogenesis, including but not limited to cell cycle progression, mitochondrial homeostasis and apoptosis. PARK2 is frequently deleted across a variety of cancer types; however, other forms of PARK2 inactivation, including somatic mutation and promoter hypermethylation/down-regulation of expression, have also been observed; cBioPortal, MSKCC, Nov. 2015). Recently, germline mutation in PARK2 has been associated with familial lung cancer.