P2RY8
小结
P2RY8编码蛋白属于G蛋白偶联受体家族，其优先被腺嘌呤和尿嘧啶激活。P2RY8在未分化的HL60细胞中适度表达，并位于染色体X和Y上。P2RY8-CRLF2发生融合导致癌症的发生。
P2RY8, a member of the G-protein coupled receptor family, is altered by mutation or fusion in lymphomas.P2RY8 is an orphan receptor that is a member of the G-protein coupled receptor family (GPCRs). GPCRs signal by association with heterotrimeric G proteins at the plasma membrane and function as exchange factors leading to G-protein activation. P2RY8 signals via the G-protein GNA13 and the downstream effector ARHGEF1, leading to activation of signaling pathways. P2RY8 is highly expressed in germinal center B cells; functional studies in murine B cells demonstrate that P2RY8 suppresses B cell growth and mediates B cell positioning in the germinal center in a GNA13-dependent manner. In addition, P2RY8 is required to promote the clustering of activated B cells within follicles in collaboration with follicular dendritic cells. P2RY8 fusions are found in patients with B-progenitor acute lymphoblastic leukemia (ALL) and ALL-associated Down Syndrome. P2RY8 predominantly fuses with CRLF2, and P2RY8-CRLF2 rearrangements are associated with relapse and poor prognosis in ALL. In addition, loss-of-function P2RY8 mutations have been identified in diffuse large B cell lymphomas (DBLCL) and follicular lymphomas; however, the function of these mutations have yet to be determined.