NTRK1是致癌基因，编码蛋白（神经营养受体酪氨酸激酶1）是一种受体酪氨酸激酶，是存在于神经细胞中的一种跨膜受体，通过结合其主要配体-神经生长因子（NGF）而激活。NTRK1由胞外配体结合结构域、跨膜结构域和包含酪氨酸激酶结构域的细胞内区域组成。NTRK1的致癌激活导致MAP激酶、PI3激酶和PLC-γ途径的自磷酸化和活化，介导细胞增殖、存活和分化。NTRK1突变和融合被发现在各种癌症中。

The NTRK1 (neurotrophic receptor tyrosine kinase 1) protein is a transmembrane neurotrophic receptor that is found in neural cells and is triggered via the binding of its main ligand, nerve growth factor (NGF). NTRK1 consists of an extracellular ligand-binding domain, a transmembrane domain and an intracellular region harboring the tyrosine kinase domain. Oncogenic activation of NTRK1 leads to autophosphorylation and activation of the MAP-kinase, PI3-kinase and PLC-γ pathways, mediating cell proliferation, survival and differentiation. NTRK1 mutations and fusions are found in various cancers.

GeneCards OncoKB My Cancer Genome