NR4A3编码蛋白是一种类固醇甲状腺激素类视黄醇受体超家族成员，编码的蛋白可以作为转录激活剂。该蛋白能有效结合NGFI-B应答元件（NBRE）。在骨骼外黏液样软骨肉瘤（EMCs）中发现该基因与其他基因相互易位。易位断裂点与核受体亚家族4、A组、成员3（第9染色体）和Ewing Sarcome断点区域1（22号染色体上）、RNA聚合酶II、TATA盒结合蛋白相关因子、68-KD（17号染色体上）或转录因子12（15号染色体上）。

NR4A3 gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15).

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