NFE2L2
小结
NFE2L2是致癌基因，编码蛋白是一种转录因子 (Nuclear factor-erythroid 2-related factor 2)，也称为NRF2，调节关键抗氧化剂和应激反应基因。在正常的细胞中，NRF2与KEAP1的相互作用将蛋白保留在细胞质中，并通过泛素化促进其蛋白酶体降解。在检测到应激信号后，KEAP1经历构象变化，防止其与Nrf2相互作用，并允许Nrf2转运到细胞核并驱动特定基因的表达。NRF2对某些化学致癌物引发的癌症形成过程可以起到保护作用。
NFE2L2 (Nuclear factor-erythroid 2-related factor 2), also known as NRF2, is a transcription factor that is important in activating antioxidant proteins to protect against certain environmental and oxidative stresses. Under normal cellular conditions, the interaction of NRF2 with KEAP1 retains the protein in the cytoplasm and promotes its proteasomal degradation via ubiquitination. Upon sensing stress signals, KEAP1 undergoes a conformational change, preventing it from interacting with NRF2 and allowing NRF2 to translocate to the nucleus and drive the expression of specific genes. NRF2 can have a protective role in cancer formation from certain chemical carcinogens.