NAB2
小结
NAB2编码蛋白（NGFI-A结合蛋白2）是NGFI-A结合（NAB）蛋白家族的成员，其在细胞核中起作用以抑制由EGR（早期生长反应）家族的一些成员诱导的转录。 NAB蛋白可以通过保守的N-末端结构域与其他EGR或NAB蛋白同源或异源多聚化，并通过两个部分冗余的C-末端结构域抑制转录。与NAB2相关的疾病包括血管外皮细胞瘤，恶性肿瘤。
NAB2 (NGFI-A Binding Protein 2) is a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains.