MYD88是致癌基因，编码蛋白是一种衔接蛋白（信号转导蛋白髓样分化初级应答88)。编码蛋白的作用是转导来自Toll样受体的信号和对先天免疫起重要作用的白细胞介素-1受体信号。通过MYD88的信号传导可以激活NFkB通路。携带MYD88功能性缺失突变的患者由于免疫功能失调更容易受到细菌感染。MYD88的激活突变，特别是L265P突变，经常在Waldenström's 巨球蛋白血症患者中发现。同样的突变也发现于淋巴瘤中，包括慢性淋巴细胞白血病和激活的B细胞型弥漫性大B细胞淋巴瘤（DLBCL）

MYD88 encodes for the signaling adaptor protein Myeloid differentiation primary response 88. It functions to transduce signaling from Toll-like receptors and the Interleukin-1 receptor important for innate immunity. Signaling through MYD88 activates the NFkB pathway. Patients with MYD88 loss of function mutations are more susceptible to bacterial infections due to immune dysfunction. Activating mutations of MYD88, particularly the L265P mutation, are frequently identified in Waldenström's macroglobulinemia patients. The same mutation is also found in lymphomas, including chronic lymphocytic leukemia and the Activated B-cell type Diffuse Large B-cell Lymphomas (DLBCL).

GeneCards OncoKB My Cancer Genome