MYCL编码蛋白是一种转录因子，是MYC癌蛋白家族成员。MYCL基因的结构与人类MYC基因家族（MYC和MYCN）的其他成员具有基本的同源性。MYCL并不像Myc普遍表达，而是优先在发育的肾和肺中表达，并且在转化潜力方面似乎不太有效。MYCL基因突变主要见于小细胞肺癌，大约5-10%的样本中发现MYCL的扩增。其他MYC家族成员的扩增也发生在小细胞肺癌，并且在某些情况下，这些扩增与MYCL扩增同时发生。

MYCL encodes a transcription factor and member of the MYC oncoprotein family involved in. The architecture of the MYCL gene shows substantial homology with the other members of the human MYC gene family (MYC and MYCN). Unlike MYC, which is expressed ubiquitously, MYCL is preferentially expressed in the developing kidney and lung, and appears to be less potent in terms of transformation potential. Reports of cancer-associated genomic alterations of MYCL are predominantly limited to small cell lung carcinomas, where MYCL is found amplified in approximately 5-10% of samples. Amplification of other MYC family members also occurs in small cell lung cancer, and in some cases these amplifications may co-occur with amplifications of MYCL.

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