LYN
小结
LYN是致癌基因，编码蛋白是一种非受体酪氨酸激酶，属于Src家族。LYN编码蛋白参与免疫应答、B细胞信号转导、生长因子信号转导和DNA损伤应答等功能。LYN是一种介体，可以根据细胞和生理背景正向或负向地调节不同的过程。LYN在不同的癌症背景下已被描述为促进肿瘤生长，侵袭，上皮间质转化（EMT）和ERK信号。LYN基因通常在多种肿瘤中（前列腺癌、乳腺癌和卵巢癌等） 发生扩增变异。
The LYN gene encodes a non-receptor tyrosine kinase of the Src family. LYN is involved in immune responses, B-cell signaling, signal transduction of growth factors and response to DNA damage, among other functions. LYN is a mediator that can positively or negatively regulate different processes depending on the cellular and physiological context. LYN has been described to promote tumor growth, invasion, epithelial to mesenchymal transition (EMT) and ERK signaling in different cancer contexts. The LYN gene is typically altered by amplification in various tumors, including prostate, breast and ovarian cancers. LYN can be pharmacologically targeted with Src-kinase inhibitors, such as dasatinib.