LMO1编码蛋白是一种转录调节因子（ Lim-domain-only protein ），用于调节转录复合物形成。 Lim-domain-only proteins (LMO1-4)的特征在于两个串联排列的蛋白质相互作用的LIM结构域，LIM结构域类似于锌指结构域，但不是介导DNA相互作用，而是介导蛋白相互作用。LMO1的表达可促进白血病的发生，并与TAL1和其他蛋白形成蛋白复合物。LMO1蛋白复合物调节已知的癌基因如MYB的转录。LMO1在神经母细胞瘤中以癌基因发挥功能。LMO1与不良生存和转移风险较高有关，但确切的作用机制尚不清楚。

LMO1 (Lim-domain-only 1, also known as TTG1 and Rhombotin 1) is a Lim-domain-only protein that functions to regulate the formation of transcriptional complexes. The Lim-domain-only proteins (LMO1-4) are characterized by two tandemly arrayed protein interacting LIM domains. The LIM domain is similar to a zinc finger domain; however, instead of mediating DNA-interactions it mediates protein-protein interactions LMO1 was first described to have oncogenic functions in T-lymphoblastic leukemia. It is was found to be located near chromosome 11 translocation breakpoints leading to overexpression in these leukemias. LMO1 expression can drive leukemogenesis and form protein complexes with TAL1 and other proteins. LMO1 protein complexes regulate transcription of known oncogenes such as MYB, one mechanism through which LMO1 leads to leukemogenesis. LMO1 is also described as an oncogene in neuroblastoma. A subset of neuroblastoma is robustly associated with germline sequence variants close to the LMO1 gene. These sequence variants lead to high LMO1 expression through differential GATA transcription factor binding. It is clear that LMO1 is associated with poor survival and a higher risk of metastasis, but the exact mechanisms of action are not well understood.

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