KIF5B编码蛋白是驱动蛋白家族成员5B，是线粒体和溶酶体正常分布所需的微管依赖性马达。可以以ZFYVE27依赖性方式诱导非神经元细胞中神经突样膜突起的形成。其相关途径是N-钙粘素信号事件和肽类激素代谢，KIF5B编码蛋白与ATP酶活性和微管运动活性相关。与KIF5B相关的疾病包括肺腺癌和肺鳞癌。在人类肿瘤中，常见的变异形式是KIF5B与ALK，PDGFRA，RET，MET发生基因融合。

KIF5B (Kinesin Family Member 5B) is a Protein Coding gene. Diseases associated with KIF5B include Blackwater Fever and Adenosquamous Lung Carcinoma. Among its related pathways are Golgi-to-ER retrograde transport and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity.Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity)

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