KDM5A
小结
KDM5A编码蛋白是赖氨酸脱甲基酶5A，是一种组蛋白3赖氨酸4（H3K4）的组蛋白去甲基化酶。KDM5A的植物同源结构域（PHD）识别未甲基化的H3K4以将酶定位到特定的染色质区域。通过染色质修饰和转录沉默，KDM5A调节细胞分化并与视网膜母细胞瘤蛋白（PRB）协同作用以控制细胞周期进程。KDM5A也影响细胞代谢和生物规律。在癌症中，KDM5A通过靶向细胞周期和血管生成基因并增强治疗抗性来促进肿瘤进展。研究显示，在白血病中，KDM5A常见变异形式是重排；在乳腺癌和头颈部癌中，KDM5A常见变异形式是扩增。
KDM5A (also known as JARID1A) encodes for lysine demethylase 5A, a histone demethylase for histone 3 lysine 4 (H3K4). KDM5A's plant homeodomain (PHD) recognizes unmethylated H3K4 to locate the enzyme to specific chromatin regions. Through chromatin modification and transcriptional silencing, KDM5A regulates cellular differentiation and cooperates with the retinoblastoma protein (pRB) in controlling cell cycle progression. It also affects cellular metabolism and circadian rhythms. In cancer KDM5A promotes tumor progression by targeting cell cycle and angiogenesis genes and enhancing treatment resistance. It is amplified in breast and head and neck cancers.