IRF4
小结
IRF4编码蛋白是干扰素调节因子4，是一种参与调节细胞因子应答和淋巴细胞发育的转录因子。IRF4可以与其他转录因子发生同源或异源二聚化以结合DNA。IRF4作为下游调节器，对免疫应答和NFkB信号转导具有重要作用。它调节B细胞和T细胞的发育和存活。其活性也参与黑素细胞色素沉着。IFR4（也称为MUM1）的表达用于分类弥漫性大B细胞淋巴瘤亚型。IRF4与IgH发生的易位已经在骨髓瘤中得到鉴定，在淋巴瘤中也发现了与其他基因的易位。IRF4的多态性也与慢性淋巴细胞白血病（CLL）易感性有关，突变在T细胞白血病和淋巴瘤中发现。
IRF4 gene encodes for interferon regulatory factor 4, a transcription factor involved in regulating cytokine responses and lymphocyte development. It can homo- or heterodimerize with other transcription factors to bind DNA. IRF4 is important for immune response and in NFkB signaling as a downstream mediator. It regulates the development and survival of B- and T-cells. Its activity is also involved in melanocyte pigmentation. Expression of IRF4 (also known as MUM1) is used to classify diffuse large B-cell lymphoma subtypes. Translocations involving IRF4 and the IgH locus have been identified in multiple myeloma and with additional gene loci in lymphomas. IRF4 polymorphisms have also been linked to chronic lymphocytic leukemia (CLL) susceptibility and mutations are found in T-cell leukemia and lymphomas.