IKZF1
小结
IKZF1基因编码Ikaros家族锌指1转录因子（IKZF1）。IKZF1在造血干细胞中起到诱导淋巴特殊化和分化的作用。作为转录因子，IKZF1通过向靶基因募集组蛋白去乙酰化酶和染色质重塑ATP酶来改变染色质并调节基因表达。IKZF1是多发性骨髓瘤中来那度胺诱导的降解物的靶点，其降解是骨髓瘤药物活性的重要组成部分。IKZF1突变和缺失在B细胞急性淋巴细胞白血病（B-ALL）中最常见，并且可能是费城染色体阳性（BCR-ABL）B-ALS白血病转化的一种机制。IKZF1基因突变与B-ALL预后不良有关。在其他白血病如急性髓细胞白血病中，很少发现IKZF1的缺失。
IKZF1 gene encodes the Ikaros family zinc finger 1 transcription factor (IKZF1). IKZF1 functions in hematopoietic stem cells to induce lymphoid specification and differentiation. As a transcription factor, IKZF1 alters chromatin and regulates gene expression by recruiting histone deacetylases and chromatin remodeling ATPases to target genes. IKZF1 is the target of lenalidomide-induced degradation in multiple myeloma and its degradation is a key component of the drug's activity in myeloma. IKZF1 mutations and deletions are most commonly found in B-cell acute lymphocytic leukemia (B-ALL) and may be a mechanism of leukemic transformation in Philadelphia chromosome-positive (BCR-ABL) B-ALLs. Mutation of IKZF1 is associated with poor prognosis in B-ALL. It is also deleted more rarely in other leukemias such as acute myeloid leukemia.