IKBKE
小结
IKBKE编码蛋白是一种丝氨酸/苏氨酸激酶，参与调节对感染和癌症的炎症反应。IKBKE在被病毒感染的细胞中被激活，与DDX3X结合并使其靶蛋白（例如干扰素调节因子（IRF3，IRF7）磷酸化。由于它们的磷酸化，IRF易位到细胞核并激活促炎和抗病毒基因（如IFNB）的转录。IKBKE还对NF-κ-B抑制剂磷酸化，导致其降解，并进一步增强促炎反应。多于30%的原发性乳腺癌中出现IKBKE的高表达，并观察到IKBKE基因的扩增。IKBKE已证明是通过对CYLD的418位丝氨酸和TRAF2的11位丝氨酸磷酸化，而表现出癌基因功能。此外，IKBKE还对NF-κ-B和Akt1磷酸化，导致更高的NF-κ-B活性。
IKBKE encodes a serine/threonine kinase involved in regulation of inflammatory responses to infection and cancer. Inhibitor of Kappa Light Polypeptide Gene Enhancer in B-Cell, Kinase Epsilon (IKBKE) is a serine/threonine kinase that has important functions in the regulation of inflammatory responses to infection as well as cancer. It is activated in cells that are infected with virus and as a result associates with DDX3X and phophorylates its target protein such as interferon regulatory factors (IRF3, IRF7). As a result of their phosphorylation IRFs translocate to the nucleus and activate transcription of pro-inflammatory and anti-viral genes such as IFNB. IKBKE also phosphorylates inhibitors of NF-kappa-B leading to their degredation and further enhancing pro-inflammatory responses. It is overexpressed in >30% of primary breast cancer and amplifications affecting IKBKE locus have been observed. IKBKE has been shown to exhibit oncogenic functions through the phosphorylation of CYLD at serine 418 and TRAF2 at serine 11. Additionally IKBKE also phosphorylates NF-kappa-B and AKT1 leading to higher NF-kappa-B activity.