ID3编码蛋白（DNA结合抑制剂3）是一种结合碱性螺旋-环-螺旋（HLH）转录因子并抑制其活性的蛋白质。ID3蛋白与组织特异性HLH蛋白（例如E蛋白）形成异二聚体，其破坏它们与DNA的结合。ID3可以调节细胞分化，细胞增殖，细胞侵袭性和血管生成。小鼠中ID3表达的丧失导致B细胞增殖缺陷和淋巴瘤的发展。ID3中的功能丧失突变在伯基特淋巴瘤中是常见的并且导致ID3转录活性的破坏。ID3在各种肿瘤中也过表达，具有生长增强和生长抑制作用，表明ID3似乎在癌症中具有背景依赖性的致癌和肿瘤抑制功能。

ID3 (Inhibitor for DNA binding 3) is a protein that binds basic helix-loop-helix (HLH) transcription factors and inhibits their activity. ID3 proteins form heterodimers with tissue-specific HLH proteins, such as E proteins, that disrupt their binding to DNA. ID3 can regulate cell differentiation, cell proliferation, cell invasiveness and angiogenesis. Loss of ID3 expression in mice results in defects in B-cell proliferation and the development of lymphomas. Loss-of-function mutations in ID3 are common in Burkitt's lymphoma and result in disruption of ID3 transcriptional activity. ID3 is also overexpressed in various tumors, with both growth-enhancing and growth-suppressing effects suggesting that ID3 appears to have context-dependent oncogenic and tumor suppressor functions in cancer.

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