GSK3B编码蛋白是糖原合成酶激酶3b，是一种在所有真核生物中都存在的多功能丝氨酸/苏氨酸激酶，参与调节胰岛素依赖性糖原合成。GSK3B编码的蛋白激酶功能是作为一种参与细胞代谢、细胞周期和增殖的细胞信号通路的重要调节因子。与大多数蛋白激酶不同，GSK3β在生长停滞细胞中具有组成型活性，并对多个外部信号进行快速和短暂的抑制响应。GSK3β的活性受位点特异性磷酸化的调控。失调的GSK3B与许多人类疾病的发展有关，如糖尿病、心血管疾病、神经退行性疾病和双相情感障碍。蛋白激酶的过度表达也参与了肿瘤的发生和癌症进展，包括卵巢癌、结肠癌、肝癌和胰腺癌。

GSK3B encodes glycogen synthase kinase 3b, a multifunctional serine /threonine kinase found in all eukaryotes. The protein kinase functions as an important regulator of cellular signaling pathways involved in metabolism, cell cycle and proliferation. Unlike most protein kinases, GSK3β is constitutively active in resting cells and undergoes a rapid and transient inhibition in response to a number of external signals.GSK3β activity is regulated by site-specific phosphorylation.Dysregulated GSK3B has been implicated in the development of a number of human diseases such as diabetes, cardiovascular disease, neurodegenerative diseases and bipolar disorder.Overexpression of the protein kinase has also been implicated in tumorigenesis and cancer progression including ovarian, colon, liver and pancreatic carcinomas.

GeneCards OncoKB My Cancer Genome