FOXP1
小结
FOXP1编码蛋白是一种DNA结合蛋白，是叉头框转录因子的P亚家族成员，主要作为转录阻遏物发挥作用。FOXP1通过与调节单元结合和募集组蛋白去乙酰化酶以及其他辅因子来调节细胞类型特异性基因表达程序。FOXP1是胸腺细胞发育、幼稚T细胞的生成、肺和食管组织的发育所必需的。FOXP1的缺失变异已在肾脏、肝脏、乳腺和子宫内膜肿瘤等多种癌症类型中检测到。FOXP1在弥漫性大B细胞淋巴瘤和肝细胞癌中呈现过表达，表明FOXP1变异的类型与肿瘤类型相关
FOXP1 is a DNA binding protein that is a member of the P subfamily of forkhead box transcription factors and primarily functions as a transcriptional repressor. FOXP1 regulates cell-type specific gene expression programs by binding to regulatory units and recruiting histone deacetylases and other cofactors. FOXP1 is required for thymocyte development, the generation of naïve T cells, and the development of lung and esophageal tissue. FOXP1 loss has been observed in a range of cancer types, including tumors of the kidney, liver, breast, and endometrium. FOXP1 has also been found to be overexpressed in diffuse large B-cell lymphomas and hepatocellular carcinoma, demonstrating that the impact of FOXP1 alterations is context specific. FOXP1 is part of a translocation observed in the MALT subtype of lymphomas.