FGF3
小结
FGF3是致癌基因，编码蛋白是一种内分泌FGF，属于人成纤维细胞生长因子家族。FGF3在内耳的形成和癌症中发挥关键作用。FGF3属于FGF7亚家族，其包括FGF3，FGF7，FGF10和FGF22。FGF根据作用机制被分为胞内分泌，旁分泌和内分泌FGF。研究显示，FGF3特异性地与WNT1结合以诱导小鼠乳腺肿瘤的发展。MCF7细胞中FGF3的内源性表达增加了致瘤潜力。
FGF3 is an endocrine FGF which belongs to the human fibroblast growth factor family which plays critical roles in inner ear fate and cancer.The human fibroblast growth factor (FGF) family comprises 22 structurally related polypeptides that play crucial roles in neuronal functions, development, and metabolism. FGFs are classified as intracrine, paracrine, and endocrine FGFs based on their action mechanisms. FGF3 belongs to the FGF7 subfamily which includes FGF3, FGF7, FGF10 and FGF22. For inner ear, FGF3 has fallen into and out of favor as a potential ear-specific inducer. Excess FGF3 can induce the formation of extra otic vesicles (ear rings), whereas insufficient FGF3 can block their formation in chick. FGF3 has been identified as a main target of mouse mammary tumor virus (MMTV) insertional activation in mouse mammary tumors. FGF3 specifically cooperate with WNT1 to induce the development of mouse mammary tumors. Endogenous expression of FGF3 in MCF7 cells increases the tumorigenic potential.