FGF19
小结
FGF19是致癌基因，编码蛋白为内分泌FGF，属于人成纤维细胞生长因子家族。 它在神经元功能，发育和新陈代谢中起着关键作用。FGF根据作用机制被分为胞内分泌，旁分泌和内分泌FGF。 FGF19是内分泌FGF，其需要α-Klotho或β-Klotho作为FGFR的辅因子。FGF19用β-Klotho激活FGFR4并表现出代谢和增殖活性。FGF19目前作为肾功能衰竭，冠状动脉疾病，肠衰竭相关肝病，糖尿病，克罗恩病和前列腺癌的生物标志物。
FGF19 is an endocrine FGF which belongs to the human fibroblast growth factor family. It plays critical roles in neuronal functions, development, and metabolism.The human fibroblast growth factor (FGF) family comprises 22 structurally related polypeptides that play crucial roles in neuronal functions, development, and metabolism. FGFs are classified as intracrine, paracrine, and endocrine FGFs based on their action mechanisms. FGF19 is an endocrine FGF which require α-Klotho or β-Klotho as a cofactor for FGFRs. FGF19 activates FGFR4 with β-Klotho and exhibits metabolic and proliferative activities. FGF19 acts as a biomarker for Renal failure, coronary artery disease, intestinal failure-associated liver disease, diabetes, Crohn’s disease, and prostate cancer.