FAT1
小结
FAT1是抑癌基因，编码跨膜蛋白，并且是参与平面细胞极性的钙粘蛋白超家族的成员。FAT1参与促进肌动蛋白介导的细胞迁移以及抑制YAP1介导的细胞增殖。FAT1是癌细胞生长的有效抑制因子，因为它具有结合β-catenin并消除其核定位和靶标转录的能力。FAT1的改变会导致减少其与β-catenin的相互作用，从而促进WNT信号转导和肿瘤发生。大多数FAT1在癌症中的变异是功能缺失性的。
FAT1 is a transmembrane protein and member of the cadherin superfamily that is involved in planar cell polarity. FAT1 is involved in the promotion of actin-mediated cell migration as well as inhibition of YAP1-mediated cell proliferation. FAT1 is a potent suppressor of cancer cell growth, owing to its ability to bind β-catenin and abrogate its nuclear localization and transcription of its targets. Alterations in FAT1 decrease its interaction with β-catenin, thus promoting WNT signaling and tumorigenesis. Although most FAT1 alterations in cancer are loss-of-function events, studies suggest that it may be both tumor suppressive or oncogenic in a context-dependent manner .