ERRFI1是抑癌基因，ERRFI1编码ERBB受体反馈抑制剂1，是一种支架蛋白并充当ERBB受体家族成员的抑制剂。ERRFI1编码蛋白也称为Mig6，充当EGF受体家族的许多成员和HGF / SF-Met信号传导的负调节物。通过与EGF受体结合，Mig6抑制其催化活性并驱动其内化。Mig6氨基末端的CRIB结构域对于蛋白质与Cdc42的结合很重要，而C末端含有ERB结合结构域，这对于对EGF受体家族成员的抑制活性很重要。Mig6在细胞信号传导，发育，体内平衡和应激反应中起关键作用。ERRFI1的缺失（由于拷贝数改变）主要见于胶质母细胞瘤，肺癌和乳腺癌；该基因的错义突变比较少见。

ERRFI1 gene encodes ERBB receptor feedback inhibitor 1. The protein, also known as Mig6, acts as a negative regulator of many members of the EGF receptor family and of HGF/SF-Met signaling. By binding to EGF receptors, Mig6 inhibits their catalytic activity and drives their internalization. The CRIB domain at the amino terminus of Mig6 is important for the binding of the protein to Cdc42, whereas the C-terminus contains an ERB-binding domain that is important for the inhibitory activity exerted on the members of the EGF receptor family. Mig6 plays a pivotal role in cell signaling, development, homeostasis and stress response. Downregulation of Mig6 has been observed in hepatocellular carcinoma, endometrial cancer cell lines and glioblastoma.

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