ERG是原癌基因，编码蛋白是一种ETS（E26转化特异性）家族转录因子，在基因调控中很重要。 在正常生理学中，ERG主要在造血细胞中表达，ERG是正常造血和内皮细胞所需的并且调节血管生成和血管稳定性。在前列腺癌和尤因氏肉瘤等多种癌症中，ERG融合是其最常见的变异形式。在前列腺癌中，大约50％的病例都存在ERG和高表达基因之间的融合，进而导致ERG的异常过表达。

ERG (ETS-related gene) is an ETS (E26 transformation-specific) family transcription factor that is important in gene regulation. In normal physiology, ERG is primarily expressed in hematopoietic cells where it is required for normal hematopoiesis and endothelial cells where it regulates angiogenesis and vascular stability. ERG fusions are the most common alterations of the ERG gene and are found in several cancers, including prostate cancer and Ewing’s sarcoma. In prostate cancer, approximately 50% of all cases harbor a fusion between ERG and a highly expressed gene (e.g., TMPRSS2) that leads to aberrant overexpression of ERG.

GeneCards OncoKB My Cancer Genome