EPHA7编码肝配蛋白受体A7（ephrin receptor A7），是酪氨酸激酶蛋白家族亚家族的一部分，并优先结合糖基磷脂酰肌醇（GPI）锚定配体。EPHA7由一个酪氨酸激酶结构域和一个细胞外结构域组成，其含有配体结合结构域、富含半胱氨酸结构域和两个纤连蛋白III型重复序列。EPHA7在结构上类似于Eph家族的其他成员，并且通过JAK2信号通路促进细胞转化、侵袭和增殖。在各种癌症类型中，EPHA7在各种癌症中表现出表达水平的差异和在致癌作用中的不同角色。研究表明，EPHA7在胶质母细胞瘤、乳腺癌和胆囊腺癌中过表达，并通过FGFR1信号通路促进细胞增殖和迁移，与预后不良相关。另有其他研究表明，EPHA7在胃癌、结肠癌、食管鳞状细胞癌和前列腺癌中通过高度甲基化引起表达下调，并与肿瘤进展相关。

EPHA7 (ephrin receptor A7) is a part of the subfamily of the protein-tyrosine kinase family and preferentially binds glycosylphosphatidylinositol (GPI)-anchored ligands. EPHA7 is composed of one tyrosine kinase domain and an extracellular domain that contains a ligand-binding domain, a cysteine-rich domain, and two fibronectin type III repeats. EPHA7 structurally resembles other members of the Eph family and is associated with promoting cellular transformation, invasion, and proliferation through the JAK2 signaling pathway. Differential expression levels of EPHA7 and diverse roles in carcinogenesis have been shown in various cancer types. Studies have shown overexpression of EPHA7 in glioblastoma, breast, and gallbladder adenocarcinoma, which promotes cell proliferation and migration through the FGFR1 signaling pathway and is correlated with poor prognosis. Other studies have shown downregulation of EPHA7 by hypermethylation in gastric, colorectal, esophageal squamous cell and prostate cancers, as well as in follicular lymphomas; and its association with tumor progression.

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