EPHA3 编码蛋白肝配蛋白受体A3(ephrin receptor A3)是一种受体酪氨酸激酶，优先结合糖基磷脂酰肌醇（GPI）锚定的ephrins，从而激活控制细胞粘附、细胞迁移、细胞扩散和增殖的下游信号通路。EPHA3在胚胎发育期间高度表达，并且在多种肿瘤类型中过表达，包括肉瘤、白血病、成胶质细胞瘤和肝细胞癌。但在肺癌、黑色素瘤和非黑色素瘤皮肤癌中却检测到EPHA3的功能缺失的突变，该基因的功能缺失突变会导致EPHA3信号减少和细胞增殖增强。

EPHA3 (ephrin receptor A3) is a receptor tyrosine kinase that preferentially binds glycosylphosphatidylinositol (GPI)-anchored ephrins resulting in activation of downstream signaling pathways that control cell adhesion, cell migration, cells spreading and proliferation. EPHA3 is highly expressed during embryonic development and is overexpressed in various cancer types, including sarcoma, leukemia, glioblastoma and hepatocellular cancer. EPHA3 loss-of-function mutations have been identified in various cancer types including lung cancer, melanoma and non-melanoma skin cancers resulting in decreased EPHA3 signaling and enhanced cellular proliferation.

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