EP300是抑癌基因，编码一种组蛋白乙酰转移酶(p300; E1A-binding protein)，是具有组蛋白乙酰转移酶（HAT）活性的转录共激活因子，其与共激活物CREBBP同源。EP300通过在基因启动子处打开染色质，募集转录机制并作为募集转录因子的辅因子来激活转录。EP300的HAT活性也可调节其它蛋白的表达，包括抑癌基因p53和组织特异性转录因子如GATA1。在罕见的急性淋巴细胞白血病病例中已经鉴定出包含EP300 HAT结构域的融合蛋白。在白血病，淋巴瘤和小细胞肺癌，宫颈癌和膀胱癌部分实体瘤中，检测到EP300的体细胞突变。

EP300 (p300; E1A-binding protein) is a transcriptional co-activator with histone acetyltransferase (HAT) activity that is homologous to the co-activator CREBBP. EP300 activates transcription by opening chromatin at gene promoters, recruiting transcriptional machinery and acting as a co-factor to recruit transcription factors. The HAT activity of EP300 can also regulate the expression of other proteins, including the tumor suppressor p53 and tissue-specific transcription factors like GATA1. Fusion proteins that include the EP300 HAT domain have been identified in rare cases of acute lymphoblastic leukemias. Somatic mutations in EP300 are found in leukemia, lymphoma and solid tumors including small-cell lung cancer, cervical cancer and bladder cancer. EP300 mutations are commonly truncating and often co-occur with loss of the wildtype allele, suggesting that EP300 functions as a tumor suppressor. Small molecule inhibitors targeting EP300 have been found to be efficacious in preclinical and mouse studies.

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