EML4
小结
EML4编码蛋白为棘皮动物微管相关蛋白质4（Echinoderm Microtubule Associated Protein Like 4），是棘皮动物微管相关蛋白家族的成员。编码的WD-重复蛋白可能参与微管形成。在非小细胞肺癌中，EML4与酪氨酸激酶受体基因发生异常融合，EML4-ALK是其主要的融合突变形式之一。与EML4相关的疾病包括肺癌和炎性肌纤维母细胞瘤。
EML4 (Echinoderm Microtubule Associated Protein Like 4) is a Protein Coding gene. This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Diseases associated with EML4 include Lung Cancer and Inflammatory Myofibroblastic Tumor.