DDR2是致癌基因，编码蛋白（Discoidin Domain Receptor 2）是一种受体酪氨酸激酶，介导几种下游信号传导通路。当受体细胞外盘状结构域与其同源配体结合时，启动了DDR2细胞内激酶结构域的自磷酸化，将导致MAPK和PI3K下游信号传导通路的激活。这些信号通路得激活会促进细胞迁移、分化、增殖和存活。DDR2活化或表达与多种癌症类型的转移有关，例如结肠直肠癌，黑素瘤和乳腺癌，具体的机制还未完全理解。DDR2体细胞获得功能性突变已经在鳞状细胞肺癌中检测到，但在其他癌种中的发生的频率较低。

DDR2 (Discoidin Domain Receptor 2) is a receptor tyrosine kinase that mediates several downstream signaling pathways. When the extracellular discoidin domain of the receptor is bound by its cognate ligand, collagen, autophosphorylation of the DDR2 intracellular kinase domain is initiated, which results in activation of several downstream signaling pathways, such as the MAPK and PI3K pathways. Activation of these pathways promotes cellular migration, differentiation, proliferation and survival. DDR2 activation or expression has been implicated in metastasis of various cancer types, such as colorectal cancer, melanoma and breast cancer through mechanisms that are not yet fully understood. Somatic gain-of-function mutations in DDR2 have been identified in squamous cell lung cancers and at lower frequencies in other cancers. Clinical responses to targeted therapy with dasatinib have been reported in patients with squamous cell lung cancer with DDR2 mutations.

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