DAXX
小结
DAXX是抑癌基因，编码蛋白（death domain-associated protein）是一种转录共抑制因子，参与转录调节和凋亡。DAXX在细胞核和细胞质中均有积累；在细胞核中，DAX与早幼粒细胞白血病（PML）核体和ATRX（A-地中海贫血/精神发育迟滞综合征蛋白）阳性异染色质区有关。在细胞质中，DAXX已被报道与参与细胞死亡调控的各种蛋白相互作用。ATRX蛋白和DAXX蛋白相互作用并发挥多种细胞学功能，包括端粒处的染色质重塑，其中它们是组蛋白变体H3.3所必需的。DAXX经常在胰腺神经内分泌肿瘤（PanNETs）中发生改变。
DAXX (death domain-associated protein) is a protein involved in transcriptional regulation and apoptosis. DAXX accumulates in both the nucleus and the cytoplasm; in the nucleus, DAXX associates with the promyelocytic leukemia (PML) nuclear body and with ATRX-positive heterochromatic regions. In the cytoplasm, DAXX has been reported to interact with various proteins involved in cell death regulation. The proteins encoded by ATRX and DAXX interact with one another and play multiple cellular roles, including chromatin remodeling at telomeres, where they are required for the incorporation of the histone variant H3.3. DAXX is frequently altered in pancreatic neuroendocrine tumors (PanNETs).