CSF1R编码蛋白是一种膜蛋白，一种细胞因子受体。CSF1作为集落刺激因子1（CSF1）的受体调节巨噬细胞产生，分化和功能。 CSF1R介导的信号传导是先天免疫的重要调节因子。 CSF1R和CSF1配体的共表达可导致癌细胞中的致瘤活性不依赖于CSF1R过表达或扩增，这表明CSF1R充当致癌基因。然而，功能丧失的CSF1R突变和剪接变异也与髓样恶性肿瘤的易感性相关。已经显示靶向CSF1R的激酶抑制剂和中和抗体可以有效靶向CSF1 / CSF1R信号传导，导致肿瘤相关巨噬细胞数量的减少。实验数据表明，CSF1 / CSF1R阻断可以通过增强肿瘤微环境中T细胞的活化来提高免疫疗法的功效。

CSF1R is a membrane protein that acts as a receptor for colony stimulating factor 1 (CSF1), a cytokine which regulates the production, differentiation, and function of macrophages. CSF1R-mediated signaling is an important regulator of innate immunity. Co-expression of CSF1R and the ligand CSF1 can lead to tumorigenic activity in cancer cells independent of CSF1R overexpression or amplification, suggesting that CSF1R acts as an oncogene. However, loss-of-function CSF1R mutations and splice variants have also been associated with a predisposition for myeloid malignancies. Kinase inhibitors and neutralizing antibodies that target CSF1R have been shown to effectively target CSF1/CSF1R signaling, resulting in a reduction in the number of tumor-associated macrophages, Experimental data suggest that CSF1/CSF1R blockade could improve the efficacy of immunotherapies by enhancing activation of T cells in the tumor microenvironment.

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