CRLF2
小结
CRLF2（细胞因子受体样因子2）基因编码I型细胞因子受体，其通过致癌JAK-STAT途径发出信号调节诸如造血系统的增殖和发育的过程。为了释放信号，CRLF2与IL7RA（白细胞介素7受体）异二聚体化，从而形成胸腺基质淋巴细胞生成素（TSLP，是一种介导B细胞前体增殖和存活的细胞因子）的受体。 CRLF2在T细胞，树突细胞，单核细胞和嗜碱性粒细胞上表达。CRLF2活化与Th2反应有关，可导致嗜酸性粒细胞增多，并且涉及哮喘，特应性皮炎和针对蠕虫感染的免疫的反应性和气道重塑。在前体B细胞急性淋巴细胞白血病中观察到CRLF2基因的重排。重排受体可通过JAK-STAT和PI3K-MTOR途径发出信号并导致转化。
The CRLF2 (cytokine receptor-like factor 2) gene encodes a type I cytokine receptor that signals through the pro-oncogenic JAK-STAT pathway, which regulates processes such as proliferation and development of the hematopoetic system. In order to signal, CRLF2 heterodimerizes with the IL7RA (interleukin 7 receptor), thus forming the receptor for thymic stromal lymphopoietin (TSLP), a cytokine that mediates B-cell precursor proliferation and survival. CRLF2 is expressed on T cells, dendritic cells, monocytes, and basophils. Its activation is linked to a Th2 response, can lead to eosinophilia, and is implicated in reactivity and airway remodeling for asthma, in atopic dermatitis, and in immunity against helminth infections. Rearrangement of the gene is seen in precursor B-cell acute lymphoblastic leukemia. Rearranged receptor can signal through the JAK-STAT and PI3K-MTOR pathways and lead to transformation.