CRKL
小结
CRKL是致癌基因，编码一种含有SH2和SH3结构域的接头蛋白（类似CRK），有利于从激酶到下游目标的信号转导。CRKL是BCR-ABL易位激酶的靶点，增强慢性粒细胞白血病（CML）的转化。CRKL可激活RAS、RAC和Jun激酶信号通路。CRKL导致的通路激活介导参与癌症不同的细胞过程，包括细胞增殖，EMT（上皮间质转化）和侵袭。CRKL扩增在肺癌和胃癌中已被证实。
CRKL encodes an adaptor protein (CRK-Like) with SH2 and SH3 domains that facilitates signal transduction from kinases to downstream targets. It is a target of the BCR-ABL translocation kinase and enhances transformation in CML (chronic myelogenous leukemia). CRKL can activate the Ras, Rac, and Jun kinase signaling pathways. Pathway activation mediates diverse cellular processes involved in cancer including cell proliferation, EMT (epithelial to mesenchymal transition), and invasion. CRKL amplification has been identified in lung carcinomas and gastric cancer. Amplification can be a means of acquired resistance to targeted therapy in EGFR lung cancer.