CEBPA是抑癌基因，编码一个基本区域亮氨酸拉链（bZIP）转录因子，可以同源或异源二聚化以结合DNA并激活转录。通过与其反式激活域的相互作用，它可以帮助招募RNA聚合酶复合物，共激活剂CBP（Creb结合蛋白）/p300和染色质修饰复合物SWI/SNF。CEBPA基因调控对造血细胞、脂肪细胞、肝细胞和上皮细胞等多种细胞的分化具有重要意义。在肺癌中，CEBPA可抑制肿瘤的发生。在造血过程中，CEBPA通过调节特异性生长因子受体和细胞周期停滞而对髓系和粒细胞分化的发展具有重要意义。CEBPA突变发现于急性髓性白血病（AML）和遗传性AML易感性综合征。

CEBPA encodes a basic region leucine zipper (bZIP) transcription factor that can homo- or heterodimerizes to bind DNA and activates transcription. Through interactions by its transactivation domain, it can help recruit the RNA polymerase complex, coactivators CBP (Creb binding protein)/p300, and chromatin modifying complexes SWI/SNF (switch/sucrose nonfermentable). CEBPA gene regulation is important for the differentiation of diverse cell types including hematopoietic, adiopose, liver and epithelial cells. In lung cancer, CEBPA may suppress tumorigenesis. In hematopoiesis, CEBPA is important for the development of the myeloid lineage and granulocytic differentiation by regulating specific growth factor receptors and cell cycle arrest. CEBPA mutations are found in acute myeloid leukemia (AML) and in inherited AML predisposition syndromes.

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