CDKN2C是抑癌基因，编码蛋白 (cyclin-dependent kinase inhibitor 2C)也称为p18或INK4C，是一种细胞周期依赖性激酶（CDK）抑制剂，有助于调节细胞周期进程。p18通过阻止CDK4和CDK6与细胞周期蛋白的结合而实现抑制。这激活了视网膜母细胞瘤（Rb）蛋白家族，其阻止了G1期到S期的转变，并可能导致细胞周期停滞或静止。p18对细胞分裂的调节以及对B细胞、肌肉和小脑发育有重要作用。p18的缺失和突变发现于多种类型的肿瘤，包括多发性骨髓瘤、淋巴瘤、胶质母细胞瘤、脑膜瘤和垂体癌，但是发生频率较低。

CDKN2C (cyclin-dependent kinase inhibitor 2C), also known as p18 or INK4C, is a cyclin-dependent kinase (CDK) inhibitor that helps regulate cell cycle progression. p18 inhibits CDK4 and CDK6 by preventing their binding to cyclins. This activates the retinoblastoma (Rb) family of proteins, which blocks the G1 to S-phase transition and can result in cell cycle arrest or quiescence. Regulation of cell division by p18 is important for B-cell, muscle and cerebellar development. Consistent with its role as a tumor suppressor, deletions and mutations of p18 are found in multiple cancer types including multiple myeloma, lymphoma, glioblastoma, meningiomas and pituitary cancer.

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