CD74
小结
CD74编码的蛋白与II类主要组织相容性复合物（MHC）结合，并且是调节免疫应答的抗原呈递的重要伴侣。它还作为细胞因子巨噬细胞移动抑制因子（MIF）的细胞表面受体，当与编码的蛋白结合时，启动逃生途径和细胞增殖。 该蛋白还与淀粉样蛋白前体蛋白（APP）相互作用并抑制淀粉样蛋白β（Abeta）的产生。在肺癌中，CD74与ROS1发生融合；在肠癌中，、CD74与NTRK1发生融合，从而驱动肿瘤的发生。
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). CD74 (CD74 Molecule) is a Protein Coding gene. Diseases associated with CD74 include Undifferentiated Pleomorphic Sarcoma and Mucinous Lung Adenocarcinoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell surface interactions at the vascular wall.