CCND3
小结
CCND3是致癌基因，编码蛋白（cyclin D3）为细胞周期蛋白D3是细胞周期的调节因子，其通过激活细胞周期蛋白依赖性激酶4（CDK4）和CDK6将细胞外生长信号传导到细胞周期。细胞周期蛋白D3不是进入细胞周期所必需的，很少在人类癌症中扩增。细胞周期蛋白D3-CDK6复合物可通过抑制糖酵解途径中的关键酶而在癌细胞中发挥代谢，促存活作用。
CCND3 (cyclin D3) is a protein that couples extracellular growth signaling to cell cycle entry through the activation of cyclin-dependent kinase 4 (CDK4) and CDK6. Upon forming a complex with cyclin D3, CDK4 and CDK6 phosphorylate and inactivate retinoblastoma (RB), thus leading to the induction of a gene expression program regulated by the E2F family of transcription factors that is important in the transition from G1 to S phase in the cell cycle. Cyclin D3 is not essential for entry into the cell cycle and is rarely amplified in human cancers. However, the cyclin D3-CDK6 complex may play a metabolic, pro-survival role in cancer cells by inhibiting key enzymes in the glycolytic pathway.